Culture  Health&Science
Israeli company produces cancer vaccine
David Shear
Published: 16.01.12, 09:23
Comment Comment
Print comment Print comment
Back to article
8 Talkbacks for this article
1. Amazing. Saudi Arabia has oil, US has weapon, Israel has....
Dr. Dan ,   Israel   (01.16.12)
something much more valuable. We would be smart to use it as a means to peace. Only nations who sign a peace treaty with us get access to the technology. Trust me, this would work. DO NOT IN UNDER ANY CIRCUMSTANCES sell it to nations that hate and want to destroy us.
2. Mael Tov ! Good Work !
Moshe ,   Usa   (01.16.12)
3. well well well...
Marcelo ,   Berlin -> Raanana   (01.16.12)
I hope the bastards hypocrites boycotting Israel will also boycott this one....KOL HAKAVOD LE ISRAEL !
4. We (humanity) figure out a cure for cancer...
Jonathan ,   MN/US   (01.16.12)
AND YET WE STILL CANT FIGURE OUT THE COMMON COLD!!
5. Look at CLDX
Jeff ,   Ann Arbor, USA   (01.16.12)
Excellent pipeline.
6. Amazing. Let's hope it will work as expected
Avi   (01.16.12)
7. Red flags
Rob Schwartz ,   New Ton   (01.17.12)
I will give the company itself the benefit of the doubt, because this was not an official press release put out by the company. Instead it is an article posted in blog format by an non-medical/healthcare organization. Still, here's red flag #1: “It’s a really big thing,” says Levy, a biotechnology entrepreneur who was formerly CEO for Biokine Therapeutics. “If you give chemo, apart from the really nasty side effects, what often happens is that cancer becomes immune [to it]. The tumor likes to mutate and develops an ability to hide from the treatment. Our vaccines are also designed to overcome that problem.” Putting aside my bias against describing a cancer vaccine as "a really big thing" (this could be a language issue) -- Levy, who is the company's CFO (where is the chief medical / scientific officer? Medical director? Why aren't they being quoted?) -- attempts to describe the evolution of metastasis that then leads to a false claim (if he were in the U.S. governed by FDA's mandates.) There is no data from the company that suggests the vaccines were designed to "overcome that problem" -- and which problem, exactly? The "immunity" problem? The "mutation" problem? The "ability to hide from treatment" problem? Each of these could be specific traits to a cancer cell, or according to Levy, would collectively describe one cancer cell. These can also be traits for either solid tumors or liquid tumors. But Levy is vague, when the investigational drug is being targeted for development against multiple myeloma, a blood cancer (liquid tumor.) Red flag #2 Claim of "Breakthrough" - Is this "breakthrough" describing the idea of using a vaccine against cancer? No: Cancer vaccines aren't a breakthrough. The immunotherapy concept has been around for decades. - Is this "breakthrough" describing the application of the vaccination concept against a specific cancer, namely multiple myeloma? No: As of November 15, 2011 there are 16 different cancer vaccine trials actively targeting multiple myeloma (Vaxil Bio's trial is listed too). - Is this "breakthrough" describing a novel target? No: The MUC1 gene has been described back in 1984 when it was first observed in human breast carcinomas - Is this "breakthrough" describing a particular characteristic of the investigational target? Maybe: According to the company's website: "Unlike other vaccines which target the entire MUC1 protein or other domains, ImMucin does not contain any non-specific epitopes, which could dilute and disturb specific anti–cancer immunity. ImMucin™ was shown to selectively be expressed on tumor cells, thereby ensuring specific anti-cancer activity. In conclusion: - Hardly a breakthrough, - may be an interesting agent to add to the mix in a cancer that currently has multiple therapeutic options (including antibody-based therapies considered as "novel" agents), - with limited, not yet started clinical trial involving round about 15 patients in one site http Free advice for the company: I'd save the big claims language until I see progress free survival and overall survival data.... because isn't a true breakthrough grounded in patients getting the outcomes that matter the most to them -- an acceptable balance between extended quantity of life with a reasonable quality of life?
8. Red flags
Super-Jew ,   Tel-Aviv   (01.17.12)
Mr Black (#7 Schwartz), you should post Blue&White, not red flags. This is not an academic publication, just a layman's news source
Back to article