The interim government accused the Muslim Brotherhood of orchestrating the attack, branding it a "terrorist organization."
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The Middle East News Agency quoted Cabinet spokesman Sherif Shawki as saying that the Muslim Brotherhood showed its "ugly face as a terrorist organization, shedding blood and messing with Egypt's security."
However the Muslim Brotherhood condemned the attack, saying in an emailed statement from the group's London press office: "The Muslim Brotherhood condemns in the strongest possible terms the attack on the police headquarters in Mansoura (region)."
"The Muslim Brotherhood considers this act as a direct attack on the unity of the Egyptian people and demands an enquiry forthwith so that the perpetrators of this crime may be brought to justice."
No one immediately claimed responsibility for the bombing in Mansoura, 110 kilometers (70 miles) north of Cairo. The attack came a day after an al-Qaeda-inspired group called on police and army personnel to desert or face death at the hands of its fighters.
Scene of car blast in Egypt, Monday night (Photo: Reuters)
The militant group, based in Egypt's volatile Sinai, and several others have claimed responsibility for a surge of attacks on security forces since a popularly-backed coup in July toppled the country's former Islamist president, Mohamed Morsi, who hails from the Brotherhood.
In response, Egypt's armed forces launched an offensive against militants in the northern part of the Sinai Peninsula in August. Coupled with the offensive and with Morsi ousted and imprisoned, Egyptian investigators have moved to put him on trial for links to militants, accusing him and the Brotherhood of being behind the wave of violence in Sinai.
According to MENA, the explosion took place at 1:10 am at the security headquarters in the city of Mansoura, in the Nile Delta province of Daqahliya, collapsing part of the five-floor building. A security official says 14 people were killed and nearly 100 injured, including the city's security chief. Most of those killed were police officers inside the headquarters, their bodies buried beneath the debris.
It was the first major attack in the Nile Delta, spreading the carnage to a new area and bringing it closer to Cairo. Previous violence that killed scores of people happened in Sinai, or in Suez Canal-area cities such as Islamilia.
Shortly after the Mansoura bombing, security forces cordoned off the whole area, closed major entrances and exits to the city and set up checkpoints to search for perpetrators, the official said, speaking on condition of anonymity because he was not authorized to talk to the media.
The death toll is expected to rise, he said. State TV called on residents to rush to hospitals to donate blood.
The official added that the preliminary investigation indicated a car bomb caused the explosion. The explosion also damaged surrounding buildings, including a bank and a theater, and wrecked dozens of vehicles, MENA said.
Egypt's Prime Minister Hazem el-Beblawi described the attack as a "terrorist incident," and expressed condolences to the families of the victims and vowed that the perpetrators "will not escape justice."
Egypt's Prime Minister Hazem el-Beblawi (Photo: EPA)
Tuesday's bombing was not the first time that the security headquarters in Mansoura was targeted. Weeks ago, an explosion went off in front of the building but caused no casualties. Since the summer coup that ousted Morsi, militant Islamists have attacked several security headquarters with car bombs or by suicide bombers.
The Mansoura attack came shortly after the Islamic militant group Ansar Beit al-Maqdis, or the Champions of Jerusalem, threatened more attacks on the military and police, saying it considers Egyptian troops to be infidels because they answer to the secular-leaning military-backed government.
The group and others based in the Sinai have claimed responsibility for a number of suicide car bombings and deadly attacks on security headquarters, including a failed assassination attempt on Egypt's Interior Minister in September with a suicide car bombing. The minister escaped unharmed.
Speaking at a public forum on Monday, Egypt's military spokesman Ahmed Mohammed Ali said the army crackdown has killed 184 militants and arrested 803 others. He said about 25 percent of those killed and arrested are foreign fighters, but didn't provide further details. Ansar Beit al-Maqdis is believed to have ties with Palestinian militants in the neighboring Gaza Strip, and officials have said other foreign militants have found refuge in Sinai during the ongoing turmoil.
Ali also said troops have destroyed about 786 tunnels between Sinai and Gaza, which the government says are used to smuggle militants and weapons. The border crossing with Gaza has been mostly closed by Egypt and Israel since Hamas took over the tiny coastal territory in 2007. Gazans rely on the tunnels for access to many commercial goods.
"We have achieved great successes. We have impacted the main capabilities of the terrorists," Ali told the gathering. "There are, however, still cells there. We will continue to deal with them with resolve and seriousness."
In Monday's message, Ansar Beit al-Maqdis said it "will be more determined to fight" the military and police if its warning is ignored. It urged them to "repent" from participating in "this infidel bastion that is at war with God and his Prophet, and stop serving in its ranks." Its statement was dated Sunday but appeared Monday on militant websites.
The group gained notoriety after expanding its operations outside of the restive northern Sinai province.
But MENA quoted Cabinet spokesman Shawki as defying the militants, saying that "such terrorist operations will not prevent us from moving forward with the road map." He was referring to the upcoming referendum on a draft constitution Jan. 14-15, a key step in a military-backed transition plan aimed at holding presidential and parliamentarian elections later next year.
Reuters contributed to this report
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