Diplomacy has so far been a total failure during a four year civil war that has divided the Middle East, killed a quarter of a million people, driven more than 10 million from their homes and left large swathes of Syria in the hands of Islamic State militants.
The mainly Sunni Muslim Arab states that support the insurgency against President Bashar al-Assad have had virtually no productive contact with either Damascus or Assad's main backers, Shi'ite Iran and Russia.
But since a nuclear deal last month between Tehran and world powers, and in the wake of battlefield losses this year by Syrian government forces, signs have emerged of some of the first real dialogue for years.
Syria's foreign minister met with his Omani counterpart in Muscat on Thursday to discuss the crisis. He was invited by Oman, an Arab Gulf state and US ally that has steered clear of the Syria crisis so far, and has acted as a regional conciliator in the past, with good relations with Iran.
"It's inching towards some kind of solution. If Russia, Iran, the United States and Saudi Arabia make a deal, there will be a deal," a diplomat tracking Syria said.
But there is no clear idea of what such a solution might be, only that there is broad agreement on the need to try again for one.
The sides still have found no clear resolution to the main dispute: the fate of Assad in any post war settlement. He has said he will not step down while Syria is in turmoil, and his enemies say there can be no peace settlement until he goes.
"People are thinking in the right way now, but they are still not giving up their current stances," the diplomat said, referring to recent statements by both sides about Assad.
Diplomats say it has been Assad's allies Russia and Iran who are the prime movers behind the latest push for detente, in the wake of Tehran's July 14 nuclear deal.
Iran, which like Russia has provided Assad with vital military and financial backing, has said it will soon present the United Nations with its own peace plan for Syria.
Russia's foreign minister Sergei Lavrov discussed Syria with his US and Saudi counterparts in Qatar this week, an unusual meeting of such senior figures supporting the opposing sides.
A Russian diplomat tracking Syria said Lavrov and US Secretary of State John Kerry "took some homework back from Doha" and needed to work on what steps would come next.
Throughout the conflict, Damascus and its allies in Moscow and Tehran have tended to be more optimistic than their enemies about the prospects for diplomacy, making the case that the Assad government could be rehabilitated in its foes' eyes.
A Lebanese newspaper affiliated with the Hezbollah movement that supports Assad even reported last week that there had been a secret high level meeting between the spy chiefs of Syria and Saudi Arabia, brokered by Russia.
Riyadh denied this, and Western officials were unable to confirm the details. If a meeting took place at a lower level, this would not necessarily be a breakthrough, since Damascus and Riyadh have quietly discussed technical issues in the past, like exchanging prisoners.
Washington has played down the prospect that the latest diplomatic flurry could yield peace, although it has offered its support.
"Everybody can hope that perhaps there'll be a turning of the page, but we're preparing for the possibility that that may not happen," Kerry told reporters on Monday in Doha.
"I know the United States is prepared to explore a diplomatic option if it presents itself, but at this moment in time, with respect to Syria or elsewhere, it has not."
Staffan de Mistura, the third person to take on the post of chief UN peace negotiator for Syria after two predecessors quit, has said he believes the sides are not ready for peace talks.
Russian LogicThe fate of Assad has long been a stumbling block to ending the conflict. The Russian diplomat said this could be resolved if the big powers helped to fashion an overall deal that included uniting rebel and government military forces and establishing a political transition.
"He's not going to disappear by himself. The only way the question of the president could be tackled is by elections," the diplomat said. "It depends on the whole package. They have to get something in return."
The past year has seen Assad's government lose control of territory, both to Islamic State and to other rebel groups that enjoy the support of Assad's Arab foes.
A major shift in strategy by Turkey in recent weeks could put further pressure on Assad's government to seek a deal.
Ankara, a NATO member and staunch Assad opponent, has agreed to let the United States and its allies use its territory for an air campaign against Islamic State. On Wednesday US forces used a base in Turkey for the first time to launch a drone strike into northern Syria, ahead of what Ankara said would soon be a "comprehensive battle" against Islamic State militants there.
But such moves could also hurt the Damascus government. Turkey has called for a protected zone in northern Syria, which could relieve pressure on rebels fighting government forces.
Syria has said it supports efforts to combat Islamic State provided they are coordinated with Damascus.