During the prime miniser's trip to New York, he addressed the UN General Assembly, met with President Barack Obama and with presidential nominees Donald Trump and Hillary Clinton.
The incident took place at the Richard Rodgers Theatre in New York when two women began shouting verbal abuse at the prime minister, calling out "Free Palestine."
The women then attempted to barge their way through the security entourage and were quickly repelled.
According to a report in the New York Post, members of the audience shouted abuse at Netanyahu as well.
Theater-goers were not happy with the Israeli prime minister. “It isn’t enough that it is hard to get tickets to a Saturday night show. Netanyahu’s arrival turned the theater into an airport,” one theater-goer wrote online.
Liz Hoffman, who was also present during Netanyahu’s visit, wrote: “It is perhaps the biggest security presence in the theater since Obama visited here. Netanyahu is in da house.”
Another spectator told the New York Post, “All the focus was on him. There was lots of applause but also boos.”