The Revolution Leadership Council of Hama told Reuters that most of the dead in the village of Tremseh were civilians. It said the village had been attacked by helicopter gunships and tanks, and that pro-government militia men then moved in and carried out execution-style killings.
There were few details on the attack, which was reported by the Local Coordination Committees activist group and the Britain-based Syrian Observatory for Human Rights.
The Observatory said it was aware of only 100 killed from sources on the ground, but the group had only confirmed the names of 30 people so far.
Death tolls are nearly impossible to independently verify in Syria, where the government restricts journalists and where more than a year of violence has convulsed much of the country.
There were few details of the violence in Hama's Tremseh area.
Activists say more than 17,000 people have been killed since the uprising against President Bashar Assad began in March 2011, and he is coming under growing international pressure to stop the violence. But as the bloodshed continues, and the conflict morphs into an armed insurgency, hopes for a peaceful transition are dimming.
AP and Reuters contributed to this report
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