Protesters threw stones and bottles at the Egyptian prime minister's motorcade on Saturday as he tried to enter Cairo's Tahrir Square after overnight clashes nearby and at the presidential palace, media reported.
Dream Live, a private television station, reported that Prime Minister Hisham Qandil left the scene after the attack.
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His office said in a statement, without elaborating, that he had been "confronted by youths and troublemakers."
"I preferred to avoid a confrontation between them and security personnel," Qandil said later on his Facebook page.
Dozens of protesters remained in the square today after several thousand demonstrators rallied there on Saturday against Islamist President Mohamed Morsi.
Hundreds of people had clashed with police in a nearby street.
Thousands of protesters denouncing Egypt's Islamist president marched on his palace in Cairo on Friday, clashing with security forces firing tear gas and water cannons in the eighth day of the country's wave of political violence.
At least one protester was shot dead and dozens wounded, witnesses said.
Protests were held in cities around the country on Friday after a call for rallies by Morsi's opponents.
Last week, Egypt's Defense Minister Gen. Abdel Fattah al-Sissi warned that the country's regime was on the brink of collapse over the growing unrest.
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