"Against the backdrop of change, we continue to pray for peace between Israel and her neighbors, while reaffirming our enduring commitment to Israel's security," Obama said in a statement.
Passover, to be celebrated next Monday, "instructs each generation to remember its past, while appreciating the beauty of freedom and the responsibility it entails," the president wrote.
"This year, that ancient instruction is reflected in the daily headlines as we see modern stories of social transformation and liberation unfolding in the Middle East and North Africa," he said of revolts that have toppled regimes in Tunisia and Egypt ,and similar anti-government rage in Libya, Yemen and Syria .
On Wednesday, State Department spokesman Mark Toner said the United States would put a "better focus" on reviving Israeli-Palestinian peace talks, after Arab uprisings crowded the agenda recently.