"I Abdo Hussameldin, deputy oil and mineral wealth minister in Syria, announce my defection from the regime, resignation from my position and withdrawal from the Baath Party. I join the revolution of this dignified people," Hussameldin said in a YouTube video uploaded on Wednesday and seen early on Thursday.
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"I say to this regime: You have inflicted on those who you claim are your people a whole year of sorrow and sadness, denying them basic life and humanity and driving Syria to the edge of the abyss," he said, adding the country's economy was "near collapse."
The authenticity of the video could not be confirmed.
Assad appointed Hussameldin, 58, to his position through a presidential decree in 2009.
"I have been in government for 33 years. I did not want to end my career serving the crimes of this regime. I have preferred to do what is right although I know that this regime will burn my house and persecute my family," he said.
The government, which is controlled by Assad's minority Alawite sect, which has dominated power in Syria for the past five decades, has effectively stopped functioning in provinces that have been at the forefront of the uprising, such as Homs and the northwest province of Idlib, opposition sources say.
They point to what they say are several killings by Assad's forces of family members of high profile defectors from the military.
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