US officials have said the attack hit a convoy of anti-aircraft weapons inside Syria bound for the militant Lebanese Hezbollah group, but Israel hasn't publicly acknowledged the airstrike.
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In the days ahead of the attack, Prime Minister Benjamin Netanyahu and other top officials repeatedly warned of the dangers of Syrian weapons falling into the hands of Hezbollah and other hostile elements in the region.
Defense Minister Ehud Barak brought the issue up at a gathering of the world's top diplomats and defense officials in Germany, initially saying: "I cannot add anything to what you have read in the newspapers about what happened in Syria several days ago."
But, addressing the audience in English, he then added: "I keep telling frankly that we said – and that's proof when we said something we mean it – we say that we don't think it should be allowed to bring advanced weapons systems into Lebanon."
Since the outbreak of the Syrian civil war, Israeli leaders have repeatedly expressed fears that if Syria were to disintegrate, President Bashar Assad could lose control of his chemical weapons and other arms.
On Saturday night, Netanyahu, who is in the process of forming a new ruling coalition, said his new government would have to deal with weapons "being stockpiled near us and threatening our cities and civilians" - an apparent reference to the deteriorating situation in Syria.
Barak said "Hezbollah from Lebanon and the Iranians are the only allies that Assad has left."
He said in his view Assad's fall "is coming imminently" and when it happens, "this will be a major blow to the Iranians and Hezbollah."
"I think that they will pay the price," he said.
France's Mali mission applauded
During the conference, Barak applauded France's decision to send combat troops to help Mali's forces fight Islamic extremists, saying it will be a deterrent to others.
He said he salutes France's leaders for their swift action.
"The French leadership has not just analyzed what should be done, but go out there but has gone out and done it - that's a very good example for the world and quite a deterring signal for the bandits and terrorists of the world."
The French launched their military operation to oust the extremists three weeks ago, and have since taken back the three main northern cities ruled by the rebels for about 10 months.