Irwin Rose, a biochemist who shared the 2004 Nobel Prize in chemistry for discovering a way that cells destroy unwanted proteins, a key for developing new cancer therapies, has died. He was 88.
Rose, along with Israelis Aaron Ciechanover and Avram Hershko, discovered how plant and animal cells use a chemical "kiss-of-death" to mark old and damaged proteins so they can be destroyed.
Janet Wilson of the University of California, Irvine, where Rose was a researcher, says Rose died in his sleep Tuesday in Deerfield, Massachusetts.