The blast took place in the northern Sinai at the entrance of the Mediterranean coastal town of Al-Arish. Residents in the city told Reuters they had heard the sound of the explosion.
No group has claimed responsibility for the attacks on the installation that crosses the increasingly volatile Sinai Peninsula. Security in Sinai was relaxed after the fall of Mubarak in 2011 as the police presence thinned out across Egypt.
The pipeline has been shut since an explosion on Feb. 5.
Egypt's 20-year gas deal with Israel, signed in the Mubarak era, is unpopular with some Egyptians, with critics accusing Israel of not paying enough for the fuel.
Previous explosions sometimes have forced weeks-long shutdowns along the pipeline run by Gasco, a subsidiary of the national gas company EGAS.
Egypt said in November it would tighten security along the pipeline by installing alarms and recruiting security patrols from Bedouin tribesmen in the area.
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