Netanyahu took to the podium at the United Nations General Assembly on Thursday, a day after Palestinian President Mahmoud Abbas accused Israel of being an occupying apartheid state, while threatening to cancel existing agreements with Israel.
Netanyahu devoted the majority of his speech to addressing his concerns regarding the recent nuclear deal with Iran, mentioning the many security problems posed by Iran.
The prime minister said that Iran has only increased its aggression since the deal was signed, increasing support for Assad, Hezbollah and Hamas, as well as setting up terror cells around the world, including in the Western Hemisphere.
He warned that once sanctions are removed, "unleashed and unmuzzled, Iran will go on the prowl."
The prime minister held up a copy of the latest book by Iranian Supreme Leader Ayatollah Ali Khamenei that he said was a "400-page screed detailing his plan to destroy the state of Israel."
Reuters contributed to this report.