The Cabinet on Thursday approved a renewed lockdown on several Jerusalem neighborhoods, including the southern Bedouin village of Hura, set to come into effect at 11pm.
Among the areas in the capital slatted for further closures is the neighborhood of Romema and the ultra-Orthodox quarters of Kiryat Sanz and Kiryat Belz.
The ongoing lockdown on the ultra-Orthodox neighborhood of Ramat Beit was also extended by a further five days.
The government ordered the lockdown on the southern town of Netivot to be lifted immediately.
Officials also approved a five-day lockdown on neighborhoods 9 and 10 in the Bedouin town Hura after coronavirus cases spiked within the community in recent weeks.
The Health Ministry reported on Wednesday that since April 12, 4,904 cases of coronavirus have been confirmed, more than half of them in Jerusalem and Bnei Brak.
The capital has seen the largest number of new cases with 1,462 confirmed in the past 18 days - a 74.6% increase in virus diagnoses while some ultra-Orthodox neighborhoods in the city remain under partial closures and travel restrictions.
Hura, which had no confirmed infections until two weeks ago, now has 69 cases, 30 of them diagnosed in the last three days.