At least three pro-Iranian operatives were killed in an air raid on a Syrian airbase near Homs, according to the London based Syrian Observatory for Human Rights.
The missile attack, attributed to Israel by Syrian officials, also resulted in an unspecified number of injured.
The observatory also noted a warehouse housing Iranian weaponry and an additional building under construction were destroyed.
The official Syrian news agency reported in the aftermath of the raid that the Israel Air Force targeted the T-4 airbase outside Homs, though their report claimed the attack caused no injuries and that many of the missiles fired had been intercepted with only four landing inside the base.
Two Syrian Air Force cargo planes arrived in the military base from Tehran, earlier on Tuesday. But there is no indication that they were in any way connected to the strike on the base.
U.S. Secretary of State Mike Pompeo said soon after the attack that he had spoken with Prime Minister Benjamin Netanyahu about "developments in the region."
Pompeo posted on his Twitter account that the conversation with Netanyahu was as "productive," and that the United States is as committed as ever to Israel's defense.
The T-4 airbase in Syria had come under attack several times in recent years targeting Iranian warehouses and weapons including drone parts for the Quds Force in the Revolutionary Guard Corps, whose commander Qassem Soleimani was killed in an American strike earlier this month.