The Syrian news agency Sana reported on Saturday, that an airstrike was carried out against targets in the Deir ez-Zor area in the east of the country, but did not attribute the attack to Israel.
The UK based Syrian Observatory for Human's Right said Iran backed militias were targeted.
Several explosions have been heard on Saturday morning in the city of Deir ez-Zor and its surroundings which are under the control of the regime forces and Iranian-backed militias, the rights group said.
These explosions have been caused by airstrikes by an unidentified military aircraft that hit Iranian-backed militia positions in Hawija Katia area and “Al-Jisr Al-Jadid Al-Tourabi,” they added.
Saudi Arabia's Al Arabiya channel reports claimed the strike was carried out by American drones.
There were no reports of injuries in the attack.
American led coalition forces have been known to operate in the area of Deir ez-Zor as have Iranian proxies.
Israel has been known to carry out strikes against targets there in the past, Although no blame has been directed at the IDF after Saturday's attack.
Syria attributed a strike on the Damascus area last month, to Israel. At least nine people were reported to have been killed in that attack which Saudi media reported, was targeting Iranian weapons shipments for the Lebanese based Hezbollah group.
According to the Observatory for Human Rights, missiles hit the Damascus international airport and where warehouses belonging to both the Syrian and the Iranian military, were hit.