The French Champions Trophy soccer match between the Ligue 1 champion and the French Cup holder will be played in Tel Aviv on August 1.
Bloomfield Stadium will stage the season-opening match after a deal with Israeli event organizer Comtec Group, the French soccer league said in a statement on Thursday.
Comtec was behind Barcelona's visit to the region in 2013, and played a role in organizing the start of the 2018 Giro d'Italia in Jerusalem.
The inaugural Champions Trophy was played in 1995 and moved abroad in 2009 when Bordeaux defeated Guingamp in Montreal. It returned to France this year because the 2020 match was played in January in the northern city of Lens after being postponed due to the coronavirus pandemic.
Mathieu Ficot, the league deputy general director, said international development was a priority for the league.
"One of the goals of our league is international expansion. We always strive to expose French clubs to a wide audience, especially in the Middle East," Ficot said.
Comtec CEO Danny Benaim also expressed his excitement ahead of the match.
"We are very proud to host the 2021 French Super Cup here in Israel. We will make this a match that will be remembered by the Israeli public, as well as by fans around the world."